Effect of antischistosomal drug [oxamniquine] of the liver function in normal and schistosomal infected mice

ABSTRACT

Effect of oxamniquine [oral single dose of 50 mg/Kg. body weight [b.w] on the liver function in normal and schistosoma manson [S. mansoni] infected mice was, biochemicaly and histopathologicaly studied. The experiments tested for 2 months. Schistosomiasis caused abnormality in the liver after 3 months from the infection characterized by marked elevation in S. GPT, S. GOT and alkaline phosphatase [AP]. Oxamniquine had no side effect in the normal mice. Moreover it had desirable effect in the infected mice as evidenced by decreasing the highly significant elevations indicated in the test enzymes. Meanwhile, no pathological alteration was observed in the liver cells of either normal or infected mice after oxamniquine administration