Therapy related acute myeloblastic leukemia following gestational trophoblastic tumor: Possible role of high cumulative dose of etoposide
KMJ-Kuwait Medical Journal. 1997; 29 (4): 423-426
em Inglês
| IMEMR
| ID: emr-45312
ABSTRACT
The development of secondary acute myeloblastic leukemia [sAML] following chemotherapy of a gestational trophoblastic tumor [GTT] is rare. Alkylating drugs are known leukemogenic agents and epipodophyllotoxins have been implicated in the causation of a distinct subset of sAML. We report a case of s AML following treatment of a gestational trophoblastic tumor with multiagent chemotherapy including alkylating agents and a high dose of etoposide. The leukemia was characterized as myelomonocytic leukemia [FAB- M4] with a normal chromosomal pattern and without any preceding myelodysplastic phase. The leukemia developed 3 years and 6 months after the first etoposide exposure. Continuous exposure to etoposide following administration of other cytotoxic drugs including alkylating drugs may increase the risk of sAML
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Leucemia Mieloide Aguda
/
Neoplasias Trofoblásticas
/
Antineoplásicos Alquilantes
/
Etoposídeo
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Kuwait Med. J.
Ano de publicação:
1997
Similares
MEDLINE
...
LILACS
LIS