Comparison of antiulcer effects of tricyclic antidepressants with cimetidine and omprazole in rats

The antiulcer effects of different tricyclic antidepressants [trimipramine, doxepin, imipramine, and amitriptyline] in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. Acute gastric ulcer was induced by oral administration of 0.6N HCI solution, 1 mL/rat. Pretreatment of animals with doxepin, trimipramine, amitriptyline, imipramine [in doses of 10,25,40, 50, and 75 mg/kg, SC], cimetidine [in doses of 50, 75, 100, 150 and 200 mg/kg, SC], omeprazole and pirenzepine [in doses of 10, 20, 30,40 and 50 mg/kg, SC] inhibited the formation of erosions dose-dependently. The ED [50] of these agents revealed that the most active agents were omeprazole, doxepin and pirenzepine, followed by trimipramine and cimetidine. Imipramine and amitriptyline had slight antiulcer activity