Modified low density lipoprotein and lipoprotein [A] as atherogenic risk factors in haemodialysis patients

ABSTRACT

Biochemical characteristics of low-density lipoprotein [LDL] particles as well as serum lipids and lipoprotein [a] concentrations were determined in 32 uremic patients on maintenance HD and 20 healthy control. The study revealed that LDL from uremic patients contained significantly increased amount of fructosyl lysine as an index for the degree of glycosylation and thiobarbituric acid reactive substances as an index for the degree of oxidation and significantly decreased amounts of sialic acid and vitamin E compared with the controls. Furthermore, lipid composition of LDL changed where triglycerides increased significantly, while cholesterol decreased significantly in patients compared with controls. All together, serum triglycerides [TG], total cholesterol [TC]/HDL cholesterol ratio and serum lipoprotein [a] [Lp [a]] were increased significantly, HDL-cholesterol was decreased significantly; while TC and LDL- cholesterol showed insignificant changes in patients compared with the controls. Lp [a] and TC/HDL ratio were significantly negatively correlated with serum albumin levels and Lp [a] was significantly negatively correlated with creatinine clearance