Role of zinc on lead induced nephrotoxicity in rat: a histological study

ABSTRACT

To determine the effects of lead and its interaction with zinc, lead acetate and zinc chloride was given alone and incombination to albino rats to study the histological changes in the kidneys. The animals were sacrificed after 7, 21 and 42 days. Lead exposed animals exhibited reduction in their body weight. There was degeneration and necrosis of PCT along with interstitial haemorrhage. These effects were minimized on administration of zinc during 7 days only this concluding a dose related protective effect of zinc on lead