Protective role of royle jelly on genotoxicity induced by indomethacin in rats

ABSTRACT

The aim of this study was to shed some light on the protective role of Royal Jelly on genotoxic potentialities of indomethacin in pregnant females, fetuses, bone marrow of mothers and spermatogonia in male laboratory rats. Normal adult female and male rats were used to investigate the teratogenic and other possible toxic effects of indomethacin on mothers and their fetuses. Females [7 to 12-day pregnant] have been treated with various doses of the drug. The prenatal doses of administered drug were 2.5 - 5 and 5.7 mg/kg body weight. It was observed that all treatments significantly increased fetal mortality rates and decreased the mean number of living fetuses. All doses used also significantly decreased the living fetal body weight and abortion rate. The chromosomal aberrations in bone marrow of mothers were presented as gaps, breaks, end to end association, centromeric attenuations. The only numerical aberration recorded was polyploidy. The samples of sperm were taken at 35th day after treatment with consecutive injection of the 3 doses for studying sperm morphology. The effect of indomethacin on sperm count, viability and testes weight was found to be significant. In male rats morphological abnormalities of sperm were big head, bananas head with broken and divided tail