Left ventricular diastolic and systolic functions in patients with syndrome X [anginia and angiographically normal coronary arteries]

ABSTRACT

Exercise performance was studied by treadmill exercise test and left ventricular filling dynamics were assessed by Doppler-derived transmitral flow pattern analysis in 25 patients with angina. The same protocol was done in 30 patients with documented coronary artery disease [CAD] and in 15 controls. Unlike the controls, patients with syndrome X [SX] and those with CAD consistently showed exercise- induced ST segment abnormalities and impaired resting left ventricular filling. The peak early diastolic flow velocity was less in SX and CAD patients than in the controls. The peak late diastolic flow velocity was less in SX and CAD patients than in the controls. There was no significant difference between the three groups as regard acceleration and deceleration time of early and late transmitral diastolic flow velocity