Effect of consanguinity on the out come of pregnancy in Karachi women

ABSTRACT

Consanguinity is relationship by blood that is being descended from common ancestors. In Pakistan marriages among tribes and cousins are common. Consequently it weakens the genetic material. Lethal mutated gene which is usually recessive are covered by normal dominant allets. Repeated marriages in the same family or tribes increases the risk of expression of lethal recessive genes. The result of repeated cousin marriages is increased risk of having offsprings with fetal abnormalities