Celiprolol versus metoprolol and propranolol on vascular reactivity and serum lipid profile in experimental animals

ABSTRACT

In the present study, the effects of the 2 cardioselective beta-adrenoceptive blockers; celiprolol and metoprolol on serum lipid profile and on the isolated aortic strip were investigated in comparison with the standard non-selective beta-blocker propranolol. The influence of the 3 beta-blockers on serum lipid profile was determined by measuring the total triglycerides [TG], total cholesterol [TG,], high density lipoprotein cholesterol [HDL-C], and low density lipoprotein cholesterol [LDL-C] in serum of adult male albino rats. Celiprolol [40 mg/kg] metoprolol [l0 mg/kg,]; and propranolol [10mg/kg]; were given orally once daily to adult rats for 2 months. Statistical analysis of the results revealed that celiprolol significantly decreased the serum levels of TG; TC; LDL-C; and significantly increased HDL-C serum levels. While, metoprolol induced insignificant changes in serum lipid profile. On the other hand, propranolol was found to significantly increase LDL-G; TG; and TC levels, while it significantly decreased HDL-C level. On the isolated rabbit aortic strip, the addition of celiprolol [l6ug/ml bath] was found to significantly decrease the contractile response of the aortic strip to different concentrations of phenylephrine. Metoprolol and propranolol, on the other hand, were found to induce insignificant changes on the contractile responses of the isolated rabbit aortic strip to phenylephrine. So, celiprolol might be a suitable alternative to the currently used cadioselective BB; when the issues of hyperlipidemia and quality of life are to be dealt with in a hypertensive cardiac patient