Effect of certain oral hypoglycemic drugs on central monoamines contents with relation to behavioral activities in adult diabetic male albino mice

ABSTRACT

The effect of glibenclamide, glipizide and gliclazide on brain norepinephrine, dopamine and serotonin contents in different brain regions of diabetic mice with correlation to behavioral activities were investigated. Alloxan-induced diabetes produced a significant decrease in norepinephrine contents in medulla, pons and cerebellum, with a decrease in dopamine contents in all tested brain regions, while serotonin contents was increased in cerebral cortex and thalamus hypothalamus. These effects were accompanied by reduction in behavioral activities of mice [sniffing, rearing, grooming, chewing, stillness, time of immobility, and pain threshold]. Sulphonylureas significantly increased brain norepinephrine and dopamine contents in different brain regions and antagonized the behavioral activities of diabetic mice. On the other h and, these drugs produced a significant decrease in serotonin contents, an action accompanied by an increase in time of immobility and pain threshold