Clinical Application of therapeutic drug monitoring for determining the effect of age, sex, smoking habits, liver impairment and cor pulmonale on serum theophylline levels in Egyptian patients

ABSTRACT

This study was carried out on 48 adult Egyptian patients suffering from either asthma or chronic obstructive pulmonary disease [COPD]. The study showed that old age, liver impairment and cor pulmonale significantly increased serum theophylline level, while cigarette smoking significantly decreases it and sex had no effect. The study showed a linear correlation between serum theophylline levels [STL] and SGOT levels, which could be used in rough prediction for theophylline dose [D] for each individual until serum theophylline level could be analyzed