Formulations and in vitro evaluations of an effervescent dosage form for diazepam, pyridoxine hydrochloride, dimenhydrinate, and ibuprofen

ABSTRACT

Different dosage forms for a certain drug could be considerably affected its bioavailability and consequently its pharmacological effect. Effervescent tablets were prepared For diazepam [2,5,10 mg], pyridoxine HCL [50 mg],. dimenhydrinate [50 mg], and ibuprofen [200 mg]. For the first three drugs, an effervescent base which was composed from sodium bicarbonate; tartaric acid; and citric acid in a a ratio of 3.44 21, respectively, was used. On the other hand, a ratio of 5.44 0.5 0.5 was used for ibuprofen. For all formulations 1.5% polyethylene glycol [PEG 6000] was used as a lubricant. The resulted effervescent tablets were evaluated physically and chemically. The results showed that hardness of these tablets was in the range of 3.5- 5.6 kg with a friability of less than 1%. At the same time, disintegration time for these talets was 1.8 - 3.0 mins. and the pH of the resulted solutions was in a range of 5.15- 7.24. The stability of the prepared effervescent tablets was also studied at 40C, 50C, and 60C for eight weeks. The calculated expiration date [t 10%] for diazepam, pyridoxine HC1, dimenhydrinate, and ibuprofen was about 2.32,2.1, 2.2, and 2.38 years, respectively. The data of this study encourage the formulation of effervescent tablet for above drugs which might affect the patient compliance and absorption of these drugs