Comparative bioavailability and pharacokinetic study between the formulated sustained release potassium chloride tablets and KCL-retard Zyma [R] tablets II

ABSTRACT

The bioavailability of the formulated enteric coated sustained release potassium chloride tablets was measured from the urinary excretion data of the drug after a single does of 40 meq k+ [5 tablets]. The cumulative excretion data showed that 80% +/- 13.56 of the administered does was excreted within 24 hours. The bioavailability of the formulated tablets was 94.87% relative of the commercially available sugar coated KCL- retard Zyma [R] tablets