Potentiation of gentamicin induced nephrotoxicity by molsidomine in rats

ABSTRACT

Reactive oxygen metabolites have been implicated in gentamicin induced nephrotoxicity. This study tests whether or not nephrotoxicity of gentamicin is associated with cellular activation or lipid peroxidation and the use of vasodilator, molsidomine, plays a role in the renal lesion. Rats were treated with a toxic dose of gentamicin alone or in combination with molsidomine for seven days. The results showed that gentamicin induced nephrotoxicity was associated with a significant activation of cellular lipid peroxidation manifested by high serum and cortical tissue malondialdehyde, and the use of molsidomine aggravates this process. These data indicate that vasodilators and in particular those with nitric oxide [NO] donating property may be extremely harmful when used gentamicin