Study of the significance of percentage of peripheral CD4+ and CD8+ T cells and the hepatitis C virus genotypes in egyptian patients with chronic hepatitis C
Journal of the Egyptian Public Health Association [The]. 1998; 73 (1-2): 41-55
em Inglês
| IMEMR
| ID: emr-48321
ABSTRACT
Sequence comparison between isolates of hepatitis C virus [HCV] indicated that HCV can be classified into a series of distinct genotypes. The aim of this study was to determine the prevalence and clinical significance of HCV genotypes, to evaluate clinical relevance of percentage of CD4+ and CD8+ T cells in blood, and to find out predictors of response to interferon [IFN] therapy in Egyptian chronic hepatitis C [CHC] patients. The present study included 61 CHC patients who were subjected to HCV-RNA detection, HCV genotyping and determination of percentage of CD4+ and CD8+ T cells in blood before and after six months treatment with IFN. Also, 20 healthy adults were enrolled as control group. Results revealed that genotype 4a is the prevalent HCV-genotype [85%] in Egypt. Only 21% of cases responded to IFN. The percentage of CD4+ T cells was significantly reduced, while the percentage of CD8+ T cells was significantly increased in patients with CHC. After IFN therapy only the percentage of CD8+ T cells was significantly reduced in non responders. Both genotype and percentage of both CD4+ and CD8+ T cells failed to predict response to IFN. It was concluded that genotype 4a is the predominant genotype in Egypt. CHC is a disease of liver which may be induced by a suboptimal immune response. Selection of CHC patients for treatment with IFN is still a controversial issue
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Linfócitos T
/
Doença Crônica
/
Subpopulações de Linfócitos T
/
Hepatite C
/
Hepacivirus
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Egypt. Public Health Assoc.
Ano de publicação:
1998
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