Mecanismes de l'hyperre'activite' bronchique

ABSTRACT

The bronchial hyperresponsiveness represents a main theme in the definition and pathophysiology of asthma. It manifests as abnormal broncho-constriction following a variety of physical, chemical and pharmacological stimuli. The mechanisms of bronchial hyperresponsiveness has been the subject of many studies in the recent years. Most of these studies displayed that bronchial hyperresponsiveness can be a result of many factors that are more or less closely bound to each other. The main other factors are the abnormal bronchial smooth muscle, the disorder of the airway autonomic nervous system, the release of mediators by bronchial epithelial and inflammatory cells and the vascular reactions. All these factors will be described in this article, their knowledge is helpful to understand and to treat the-asthma