new method [nonivasive] for assessment of brain intergral functions in senescence: correlation of a neuropeptide with biological factors

ABSTRACT

This study was carried out on 10 young controls and 20 senescent individuals, 6 of which proved to be demented. For all subjects, the neuropeptide neuron specific enolase [NSE] was measured. NSE was significantly higher in geriatric than younger control P=0.01. 6 demented patients were still more high as compared with geriatric non demented 31, 21.2, respectively, P=0.0001. A correlation was found between those with high [NSE] as regards absence of milk in the diet, absence of physical and mental activity, habitual smoking, all these correlation were statistically significant P=0.0002, P=0.000001 and P=0.00003. It was concluded that simple assay of NSE in the serum dispose diagnostic and prognostic as regard early neuronal death among geriatric patients