Effect of some antioxidant [vitamin A, vitamin E, vitamin C] on plasma and tissues histamine concentrations in diabetic rats
New Egyptian Journal of Medicine [The]. 1998; 19 (1): 30-36
em Inglês
| IMEMR
| ID: emr-49093
ABSTRACT
The present study was carried out on adult male albino rats, experimentally made diabetics, to clarify whether some of the antioxidants exemplified by vitamin A, vitamin E and vitamin C, had any effect on the elevated plasma and aortic histamine concentrations suggested to be [at least partially] contributing to the early development of atherosclerotic changes in diabetics. In addition, an investigation of their possible effect on the activities of the aortic enzymes, histidine decarboxylase [HDC] and diamine oxidase [DAO] was included as well. Diabetes was induced in rats using alloxan. The animals [confirmed to become diabetics] were treated with the above mentioned drugs for 2 months. Plasma and aortic tissue histamine concentrations, aortic HDC and DAO enzymes activities were determined. Results of the present study had shown a statistically significant alteration in these parameters in the direction of the values recorded in the non-diabetic normal animals groups
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ácido Ascórbico
/
Ratos
/
Vitamina A
/
Vitamina E
/
Histamina
/
Diabetes Mellitus Experimental
Limite:
Animais
Idioma:
Inglês
Revista:
New Egypt. J. Med.
Ano de publicação:
1998
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