Effects on antithyroid agent [carbimazole] on thyroid glandul of Guinea pig with reference to hypertrophy of follicular cells

ABSTRACT

Effect of Carbimazole [antithyroid drug] on thyroid gland of guinea pig was noted Normal healthy male guinea pigs were divided into two groups, one group was given carbimazole treatment orally for 30 - days, the other group remained untreated and served as control. Histological observations showed enlargement [hypertrophy] of thyroid follicular cells with a significant decrease in the diameter of lumina of follicles amount of colloid and some increase in the diameter of follicles measured. An increase in connective tissue elements and vascularity was noted too. But all these changes were not very extensive because the duration of goitrogen [Carbimazole] treatment was too short [30 days] for such an animal [guinea pig] whose thyroid hormone metabolism is very slow with delayed TSH response to alter changes in histological picture of thyroid gland