Laboratory assessment of osteoporosis among egyptian postmenopausal females

ABSTRACT

Osteoporosis has been a long recognized disorder even if its causes have not. The present work was a pilot trial to assess the,magnitude of the problem of osteoporosis among fractured cases at Al-Zahraa and El'Hussien U.H. Different lab. Factors which might affect bone mineral density [BMD] among postmenopausal females in Egypt were studied hoping to provide guidelines for prevention of osteoporosis .35 Postmenopausal women for at least 5 Years and free from any disease that may affect bone mineral desnity were selected and divided into two groups according to imaging techniques for assessment of osteoporosis 1.osteoporotic group induded 21 women.2.Borderline group induded 14 women.A third monosteoporotic group induded 15 women were taken as a control group.All cases were subjected to routine lab.investigations, seruam albumin, alkaline phosphatase total calcium, inorganic phosphate,serum ionized calcium was indirectly calculated in addition to determination of serum osteocalcin and F.S H. the level of alkaline phosphatase was Significantly higher in osteoporotic compared to borderline [rho<0.05] and non osteoporotic [rho<0.05]. Its level was higher in cases of vertebral fractures compared to nonfractured cases.There was no statistically significant difference between the three groups in all other studied biochemical parameters such as serum calcium, phosphorus, ionized calcium and osteocalcin