effect of norplant [long term contraceptive] on the uterus of female albino rats

ABSTRACT

To study noticeable changes in the status of endometrium of uterus in female albino rats with long term contraceptive Norplant. Design: Light microscopic study of uterus of female albino rats with Norplant therapy. Setting: Department of Anatomy, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre, Karachi. Subjects: Sixty Six adult female albino rats were divided into six group A, B, C, D, E and F, and each group comprising of six animals, group 'A' served as age-match control, group 'B', 'C', 'D', 'E' and 'F' received subdermal insertion of single rod of Norplant at the interval of 13 days respectively. All the animals were sacrificed at their schedule time and uterus was removed, processed for paraffin embedding and stained with H and E and also with special stains. All the observations were statistically analysed. In Norplant treated animals the thickness of endometrium demonstrated a highly significant increase in groups 'B', 'C', 'D', 'E' and 'F' when compared with age-matched controls. The height of epithelial cells showed a highly significant decrease, the connective tissue fibres also showed a marked increase. On the basis of present study, it is concluded that Norplant initiate cellular injury which causes damage to the tissue and produces fibrosis