Role of ATP-sensitive Potassium channels in contractility of isolated gall bladder from guinea PIG

ABSTRACT

This study was planned to investigate the role of KATP channels on the cholinergic contractile response of isolated gall bladder from guinea pigs. The results demonstrated that carbachol [muscarinic agonist] in concentrations 1, 2, 4 and 8 mug/ml produced a significant and concentration-dependent increase [r = +0.9811] in the isolated gall bladder contractility. Preincubation of selective opener of KATP channels [minoxidil] with suspended tissue, in organ bath, in different concentrations [1, 2 and 4 mug/ml] caused a significant and concentration-dependent reduction [r = +0.9842] in the contraction induced by submaximal concentration of carbachol [2 mug/ml]. These results supported the hypothesis that KATP channels play an important role in the muscarinic contractile response of isolated gall bladder from guinea pig