real effect of toxoplasmosis on the outcome of pregnancy

ABSTRACT

A prospective study was carried out on 250 cases of pregnant women attending medical centre of Basrah University in their 1st trimester of pregnancy with an age range of 15-45 years from 1/7/1993-10/8/1996, to find out the real effect of toxoplasmosis on the outcome of pregnancy. The subject comprises of [150] cases of acute maternal toxoplasmosis during pregnancy, [115] of them had history of habitual abortion [history of 3 or more consecutive abortions] and 35 cases of sporadic abortion, the other [100] were taken as a control group [normal pregnant women]. All recently infected patients were treated with spiramycin or sulfadiazine according to the availability of drugs, in a dose of 250mg four times daily 14 days or 500mg twice daily for spiramycin or sulfadiazine respectively. The study shows that 54% of habitual abortion group their pregnancy ended by abortion, 10.5% of them go into preterm labor and 30.5% term pregnancy [6 of them lost follow up]. The study also show significant increase in the incidence of C/S [caesarean section] 15.2% in the habitual abortion group as compared to 6% among normal pregnant women, with also significant increase in the perinatal mortality rate among habitual abortion group as compared to normal pregnant women. 50% chance of congenital anomaly among perinatal death in habitual abortion group as compared to 25% among normal pregnant women