First derivative spectrophotometometric analysis of isradipine in the presence of its degradation products

ABSTRACT

A stability indicating first derivative spectrophotometric method had been proposed for the evaluation of isradipine in pure form and pharmaceutical formulations. The method depends on measuring the delta-A/delta-gamma values at 248 nm where the degradation products do not interfere. It was also determined that the excipients in the tablet and capsule preparations did not interfere with the assay. The suggested procedure showed a linear relation in the range 5-35 mug.ml -1 on plotting delta-A/delta-gamma as a function of concentration. The mean accuracy was found to be 100.1 +/- 0.95