Synthesis of some thiazolidinone and triazole dderivatives of expected antimicrobial activity

ABSTRACT

New derivatives of semicarbazide [5] and thiosemicarbazide [6] had been synthesized together with new substituted alkyl and aryl 1, 2, 4-triazoles [7] and thiazolidinone [8] obtained by cyclizing the appropriate thiosemicarbazide [6]. Screening for antibacterial and antifungal activities using preliminary scan by the agar plate inhibition zone method, followed by MIC versus ampicillin and clotrimazole revealed high activity for compounds [5-c] and [7-a]. The partition coefficient of the most and least biologically active compounds was determined and the results were reported