Formulation and in-vitro evaluation of levonorgestrel as well as copper releasing iud [procopper iud]

ABSTRACT

The addition of levonorgestrel to copper T 380 IUD carried on procopper IUD aimed at the improvement of contraceptive efficacy and minimizing its side effects and complications. In-vitro study of procopper IUD was carried out by evaluation of the release characteristics of levonorgestrel as well as copper from procopper IUD. The interaction, if any, of levonorgestrel with copper and /or elastomer was studied. The study of the release profile of levonorgestrel indicated that it was best fitted to zero order kinetic. It revealed that there is neither an interaction nor degradation for either levonorgestrel or copper during preparation or release