Synthesis and antimicrobial activity of certain pyrimidine derivatives

ABSTRACT

Hydrazinolysis of 3 gave compounds 4, 5 and 6 according to reaction conditions. Certain fused pyrimidine derivatives such as triazolo compound [7] and tetrazolo [8] were obtained from the reaction of 4 with CS2/NaOH and NaNO2/HCL, respectively. Refluxing 4 with chloroacetyl chloride yielded compounds 13 and 15 according to reaction conditions. On the other h and, reacting 3, 5 and 6 with some aldehydes gave 9a-e, 17a-e and 22a-g. Treating 5 with acetyl acetyl acetone and isothiocyanates afforded compounds 18 and 19a, b, respectively. Condensation of 1, 4, 5 and 6 with p-toluene sulfonyl chloride furnished 11, 12, 16 and 21, respectively. The benzyl derivative [23] was converted into the chloroderivative [24] which was reacted with some amines to yield 25. Also, compound 26 was obtained from 23. Some of the synthesized compounds were screened for their antimicrobial activity