neuro-behavioural pharmacological study on the effect of insulin in normal and diabetic adult male albino mice

ABSTRACT

Effect of insulin [0.5, 1 and 2 IUkg-1] on monoamines and gamma aminobutyric acid [GABA] contents in different brain regions of normal and diabetic mice with a relationship to their behavioral activity was investigated after seven daily SC doses. Non-treated alloxan-diabetic animals showed a significant decrease in norepinephrine [NE] content in the medulla, pons and cerebellum. The dopamine [DA] content was also reduced in all tested brain regions. On the other h and, serotonin [5-HT] was significantly increased in cerebral cortex and thalamus-hypothalamus. No change in mice brain gamma GABA content was observed after alloxan-induced diabetes