Oral immunization of mice against schistosoma mansoni using drinking water from trays contraining biomphalaria Alexandria infected with schistosoma mansoni

ABSTRACT

Water collected from trays containing Biomphalaria alexandrina infected with Schistosoma mansoni at the time of cercariae shedding [SmISW] and trays containing clean, non-infected, B. Alexandrina [NISW] and underground water [UW], were filtered used as a drinking water for 3 groups of albino mice males. After 2 months, blood samples were collected from the 3 groups and serum was tested for anti-cercarial IgG, then mice were infected with 150 S. Mansoni cercariae. 8 weeks after infection, mice were perfused and adult S. mansoni worms were counted. Anti-cercarial IgG was positive in 23 out of the 28 samples collected from mice drinking SmISW and only in 2 out of the 21 samples collected from mice drinking NISW, while all samples collected from mice drinking UW were negative for anti-cercarial IgG [X2 = 45.897, P <0.001]