Effect of high and low isoniazid dosage in the combined treatment of pulmonary tuberculosis

ABSTRACT

Two randomly selected groups pf patients suffering from moderately advanced pulmonary tuberculosis were treated for six months with 300 or 600 mg. Of isoniazid daily combined with 12 g. of PAS daily. The patients with high-dosage isoniazid were also given 300 mg. of pyridoxine. The results of treatment were assessed as regards sputum conversion and changes in x-ray. There was no significant difference in therapeutic response between the two groups