Medical Journal of the Islamic Republic of Iran. 1999; 13 (2): 119-123
em Inglês
| IMEMR
| ID: emr-51780
ABSTRACT
Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that SCID [severe combined immunodeficiency] mice acquired immunity to C. muris infection if injected with immunocompetent splenocytes. To investigate the role of the splenic donor B-cells in this immunity, groups of CB-17 SCID mice received BALB/c splenocytes, or splenocytes depleted of B-cells by immunomagnetic separation before infection. Both groups recovered from infection at similar times and displayed little difference in patterns of oocyst excretion. Subsequently, B-cells and serum anti-parasite antibodies were found only in mice reconstituted with unfractionated spleen cells. These results suggested that B-cells may not normally be required in immunity against Cryptosporidium
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Linfócitos B
/
Criptosporidiose
/
Camundongos
/
Formação de Anticorpos
Limite:
Animais
Idioma:
Inglês
Revista:
Med. J. Islamic Rep. Iran
Ano de publicação:
1999
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