Low levels of maternal plasma angiogenin in cases with abnormal umbilical artery flow velocity waveforms

ABSTRACT

This study was conducted to estimate angiogenin [ANG] plasma levels [as an angiogenic factor involved in placentation] in pregnancies complicated with abnormal umbilical artery flow velocity waveforms [UAFWs] and uncomplicated pregnancies in the same gestational age. The study included 80 pregnant women with gestational age [GA] from 34 to 39 weeks and singleton pregnancy. Doppler velocity waveforms of the umbilical artery of the fetus were assessed and the cohort was classified into two groups according to the findings of Doppler study Group I [n = 40] with abnormal UAFWs and Group II [n = 40] with normal UAFWs. Plasma ANG levels were estimated with an enzyme-linked immunosorbent assay [ELISA]