clinico pathologic and immunohistochemical study of dedifferentiated liposarcoma

ABSTRACT

Twelve cases of dedifferentiated liposarcoma with neural like or meningeal-like whorling pattern, metaplastic bone formation, fibrosarcoma or hemangiopericytoma like area were studied. Most of the tumors were huge masses [ranging from 2.5-60 cm]. Histologically, the tumors revealed in addition to areas of well differentiated liposarcoma discrete nodules consisting of hypercellular and spindle to ovoid cellular proliferation arranged in tight concentric whorls resembling neural tumors of meningiomas. Metaplastic ossification was present in eight of 12 tumors and consisted of variable amounts of osteoblast rimmed bone trabeculae situated at the periphery of the whorled areas or intimately mixed with the whorled cellular component. Immunohistochemical studies were inconclusive in determining the nature of the dedifferentiated whorled element and others