Apo-lipoproteins A-I and B and lipoprotein [A] in recent myocardial infarction with and without diabetes

ABSTRACT

In this study, the plasma lipids [total cholesterol [TC], low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc] and triglycerides]], apo A-1, apo B, Lp[a], TC/HDLc, LDLc/HDLc and apo B/apo A-1 ratios were measured in 120 males, aged 25-65 years, 40 normal controls and 80 patients with recent MI [45% of them had non-insulin-dependent diabetes mellitus]. Each group was divided into four subgroups according to age Group 1 [>25-35 years], group 2 [>35-45 years], group 3 [>45- 55 years] and group 4 [55-65 years]. From the results obtained, it was concluded that lipid abnormalities might be considered an independent risk factor for development of MI. Apo-B, Lp[a] and the ratio apo-B/apo-A may be better predictors to the risk of atherosclerosis than other lipid abnormalities, especially when total cholesterol level is within normal Lp[a]