Participation of angiotensin converting enzyme, prostaglandins and nitric oxide and possibility of their interaction in glycerol induced acute renal failure [A high microscopic, semi quantitative study]
Tanta Medical Journal. 1999; 27 (2): 959-74
em Inglês
| IMEMR
| ID: emr-52923
ABSTRACT
This study was performed using adult male albino rats and acute tubular necrosis was induced by glycerol injection into the hind limbs. Inhibitors for angiotensin converting enzyme [ACE], prostaglandins [PG] and nitric oxide [NO] synthase were injected intraperitonealy before and after glycerol injection to study their roles in acute renal failure and the possibility of their interaction in the kidney in a similar pattern to that takes place in the heart. Tubular damage occurring was semi-quantified in kidneys of different groups. ACE inhibitor [perindopril] was found to reduce the glycerol-induced acute tubular necrosis establishing the injurious role of angiotensin converting enzyme in the pathogenesis of this condition. Injection of either PG synthesis inhibitor [voltaren] or NO synthase inhibitor [L-NAME] has caused increase of the glycerol-induced acute tubular necrosis indicating that both prostaglandins and NO has renoprotective effects. Injection of either PG synthesis inhibitor [voltaren] or the NO synthase inhibitor [L-N AME] together with the ACE inhibitor impairs its renoprotective effect denoting that prostaglandins and NO may mediate this renoprotection
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Inibidores da Enzima Conversora de Angiotensina
/
Prostaglandinas
/
Substâncias Protetoras
/
Modelos Animais
/
Interações Medicamentosas
/
Glicerol
/
Histologia
/
Rim
/
Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Revista:
Tanta Med. J.
Ano de publicação:
1999
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