Resultats d'un protocole prospectif de traitement de la maladie de hodgkin de l'adulte

ABSTRACT

To report the results of an adapted protocol of treatment of Hodgkin disease in Tunisian patients. 70 patients[47 males and 23 females, sex-ratio=2,04] with a mean age of 38,5 years [15 to 75] are enrolled in a therapeutic protocol to the prognostic factors and based on chemotherapy with MOPP/ABV or hybrid associated to radiotherapy. We perform an evaluation of response to chemotherapy after the 4th cycle, after the 6th cycle and then at the end of the protocol. Our population is characterized by the frequency of young patients [34% between 30 and 40 years], Histologic types 2 and 3 [45 and 48%] and advanced disease with 60% of stages III and IV. After the 4th cycle, 32 patients [45%] are in complete response and 31[44%] in partial response, while 6 patients [9%] progress under chemotherapy. After 6 cycles, we observe 44 in complete response[72%] including 46% of the bad responders after 4 cycles. At the end of the protocol and on the 58 evaluable patients, 50 remain in complete response [86%]. We observe 5 deaths occurred in 3 progressing patients and in 2 patients by infection after chemotherapy. 5 year actuarial and disease-free survival is 60% and 56% and median survival is 83 months. In the univariate analysis, response to chemotherapy represent the unic significant prognostic factor