Recherche d'une anomalie constitutionnelle de l'hemostase dans les thromboses

ABSTRACT

Research of abnormality of heamostasis in thromboembolic disease is very important. In this work, we have studied resistance to activated protein C. Antithrombin III, Protein C, protein S and anticardiolipin antibody in 30 patients who have past history of arterial and venous thrombosis, and in a control population of 25 healthy subjects. We have reported one case [4%] of resistance to activated protein C in healthy subjects and 6 cases [20%] in patients; 4 deficiences of antithrombin III, I deficiency of protein S, and 3 patients with anticardiolipin antibody. The clinical entity of these abnormalities of heamostasis between resistance to activated protein C and deficiencies of coagulation physiologic inhibitors