study of homocysteine level in patients with coronary artery disease

ABSTRACT

Thirty five patients were selected for this study. Twenty of them were suffering from occlusion of less than two coronary arteries as proven by coronary angiography. The remaining fifteen patients were having two or more affected coronary arteries. Fifteen control healthy persons were included in the study. All the subjects were not risky, i.e. non smoker, not diabetic, not hypertensive and with negative family history of coronry artery disease [CAD]. All subjects were investigated for plasma homocysteine and folic acid levels, also serum blood glucose, creatinine, triglycerides, total cholesterol, HDL-C and LDL-C were done. The results showed that total plasma homocysteine [Hcy] was statistically significantly higher in the patients group than in control. A non significant lower level of plasma folate in patients than control was found with negative correlation between the level of Hcy and folate. Also no significant correlation was found between the level of Hcy and the levels of F.B.S., Triglycerides, total cholesterol, HDL-c, LDL-c or serum creatinine. Results in patients group having less than 2 affected coronary arteries [group A] and patients group having 2 or more affected vessels [group B] showed that; total plasma Hcy level was non-significantly higher in group [B] than in group [A], and plasma folic acid level was non significantly lower in group B than in group A