role of Dimethyl Dimethoxy Biphenyl Dicarbozylate [DDB] in carbon tetrachloride [CCL 4] induced hepatotoxicity

ABSTRACT

The aim of this study is to investigate the role of dimethyl dimethoxy biphenyl dicarboxylate [DDB], a Chinese drug, in the prophylaxis against liver toxicity induced by carbon tetrachloride [CCl4]. 120 male albino rats were included in this study and classified into 3 groups Group 1 [40 rats] is a control group while groups two and three [80 rats] were chronically intoxicated with CCL4 [100 mu L/100g body weight] orally every day for four weeks. Out of these two groups, group three [40 rats] was treated with DDB [20 mg / 100 gm body weight] orally every day. Liver function tests were done at the end of the study to estimate the degree of hepatotoxicity and the protective role of DDB. The liver function tests included are serum ALT, serum AST, serum ALP, bilirubin [direct, indirect and total], total proteins, serum albumin and albumen globulin ratio. The results of the study revealed that chronic administration of CCL4 greatly affected the liver as indicated by severely liver functions, while DDB seems to have a protective effect against CCL4 induced hepatotoxicity reflected by greatly improved liver function tests