Influence of the states of dehydration and rehydration on the in-situ intestinal absorption of calacctose and clucose in rats

ABSTRACT

This work aimed to evaluate the influence of an experimental model of diarrhea as well as the dehydration and rehydration rats. Reproducible model of mild and severe infectious diarrhea was produced by peroral challenges with Salmonella typhimurium in adult male rats. The in situ intestinal absorption of galactose and glucose was evaluated along 90 minutes in case of diarrhea in the presence and absence of oral rehydration solution as well as after rehydration. The utilized concentration of galactose was 325 mg%. Absorption was evaluated by determining the circulating fractions of galactose and glucose as well as the rate constants of absorption [K1 and K2]. A statistically significant reduction in the circulating amounts of sugar was occurred in the infected animals