Influence of the states of dehydration and rehydration on the in-situ intestinal absorption of histidine

ABSTRACT

In this study, experimental models for mild and severe infectious diarrhea were produced by peroral challenge with Salmonella typhimurium. The in situ intestinal absorption of histidine was evaluated along 90 minutes in the cases of diarrhea in presence of saline or oral rehydration solution [ORS] as the perfusion fluid and rehydration solution ORS following exposure to diarrhea. The concentration of histidine was 18.1 mg%. Significant differences in absorption and exsorption of histidine have been obtained according to the animal condition and the perfusion fluid. Diarrhea disturbed the amino acid pool. The presence of ORS augmented the transport of histidine in the diseased animals