Assessment of some roles of the spleen in humoral immunity in patients, with Schistosomal hepatic fibrosis and splenomegaly

ABSTRACT

The study was conducted on twenty patients suffering from Schistosomal hepatic fibrosis and splenomegaly to assess the role of the spleen in humoral immunity by comparing splenic arteriovenous immunoglobulin differences in relation to systemic and splenic tissue levels and the demonstration of immune complex in the spleen. The results of this study show that the spleen is immunologically active in case of schistosomal hepatic fibrosis sharing in the synthesis of both IgG and IgM in excess amounts due to its activation by schistosomal antigen, while it has no significant effect on IgA