Effect of 5-fluorouracil plus vitamins A and E on methotrexate toxicity
MJFCT-Mansoura Journal of Forensic Medicine and Clinical Toxicology. 2000; 8 (1): 59-77
em Inglês
| IMEMR
| ID: emr-54704
ABSTRACT
The synergistic sequential administration of methotrexate [MTX] and 5-fluorouracil [5-FU] plus vitamins A and E was investigated in 60 mature albino rats. The animals were divided into six equal groups, five test groups and a control one that received distilled water. The results of the hematopoietic elements revealed non- significant differences between scheduling of MTX after a priming dose of 5-FU plus vitamins A and E or 5-FU plus vitamins A and E and the control; while BW and BM cellularity showed a very mild reduction with the group of prior administration of 5-Fu plus vitamins to MTX. The simultaneously treated group revealed a moderate reduction in BW and BM cellularity with a significant reduction in hematopoietic elements. However, a sequential treatment with MTX, followed by 5-FU plus vitamins A and E and MTX alone resulted in a marked reduction in BW and BM cellularity, together with an extremely highly significant reduction in hematopoietic elements
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Contagem de Plaquetas
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Próstata
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Ratos
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Testículo
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Testosterona
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Vitamina A
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Vitamina E
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Hemoglobinas
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Células da Medula Óssea
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Substâncias Protetoras
Limite:
Animais
Idioma:
Inglês
Revista:
Mansoura J. Forensic Med. Clin. Toxicol.
Ano de publicação:
2000
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