Beta-blockers and renal ablated rats

ABSTRACT

This study was conducted to compare the effects of carvedilol, celiprolol and propranolol on some renal function parameters, oxidative stress profile and histopathological features in renal ablated rats and to evaluate the effects of supplementation of celiprolol or propranolol treatment with vitamin E on the previously mentioned parameters. It was concluded that vasodilator beta-blockers with antioxidant activity as carvedilol offered renoprotective effects more than propranolol. Carvedilol exhibited an increasing histopathological and functional end-organ protection in renal ablated rats. The reduction of plasma renin activity and lipid peroxidation may contribute to its renoprotective effects. The addition of vitamin E to celiprolol or propranolol treatment was mandatory to improve renal function and lipid peroxidation in partially ablated rats