Prevention of post surgical peridural fibrosis using new anti-adhesion barrier gel

ABSTRACT

A prospective study was done on 40 patients [20 as controls and 20 for which Adcon-L was used]. All patients undergone first time unilateral, single level lumbar discectomy in a trial to evaluate the safety and effectiveness of Adcon-L as an adjunct to surgery to inhibit peridural scar and related symptoms following lumbar discectomy. Patients were followed up and evaluated six months postoperatively both clinically and by MRI. Radicular pain was recorded using a [0-10] standardized visual analog scale in which 0 = no pain and 10 = excuriating pain. Scar was scored on 0-4 scale on MRI, in which 0 = no scar and 4 = more than 75% of the MRI field containing scar. The results were promising as there was an increase in the number of patients with minimal or no scar by 250% increase. The number of patients having extensive scar was reduced in Adcon group by 83.3%. No major complications were encountered