Cassava, protein and iodine interaction in the thyroid status of rats
Pakistan Journal of Scientific and Industrial Research. 2000; 43 (3): 168-176
em Inglês
| IMEMR
| ID: emr-54986
ABSTRACT
The possible synergistic role of dietary cyanide from cassava, low iodine intake and protein deficiency and/or imbalance on the thyroid status and goiter endemia in Akungba and Oke-Agbe villages in Akoko area of south-western Nigeria was investigated using rats as model. Thirty [30] weaning albino rats were fed on corn starch or cassava as the major source of carbohydrates, 3.5 and 10.0% levels of protein supplied by either casein or Amaranthus viridis and a salt mixture with or without iodine for 42 days. Cassava with a total hydrocyanic acid [HCN] content of 25 mg kg-1 DW did not cause growth depression when fed to rats with casein at 10% protein level, Iodine deficiency resulted in slightly higher weight gain while protein deficiency especially the vegetable rations caused significant growth reductions. Interaction between cassava/iodine deficiency and protein imbalance, especially in the vegetable rations, caused a significant increase in the weight of the thyroid gland when expressed as% of body weight. Dietary cyanide caused a significant increase in serum and urinary thiocyanate levels while iodine deficiency caused a significant reduction in the plasma protein-bound iodine [PBI]. These results would partially explain the goiter endemia in Akungba and Oke-Agbe villages whose nutritional status was mimicked in these experiments
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Deficiência de Proteína
/
Ratos
/
Proteínas Alimentares
/
Manihot
/
Cianetos
/
Bócio
/
Iodo
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Sci. Indust. Res.
Ano de publicação:
2000
Similares
MEDLINE
...
LILACS
LIS