Withdrwal effects in estrogenized mice testis a histological study

ABSTRACT

Animals selected for this experiment were mature male albino mice which were divided into control " A" [subgroups A 1 and A2] and experimental "B" [sub groups B1 and B2] groups. Estardial 17- beta, 50 ug/100 g body weight/day was administered to the experimental animals for one week. Group BI sacrificed at the end of 3rd week exhibited decreased body and paired testis weights. Diameter of seminiferous tubules were markedly reduced along with degeneration of spermatogenic cell lineage, Sertoli cells,l Leydig cells and blood vesels in the interstitium. Group B2 sacrificed at the end of 6 the week revealed improvement in the body and paired testis weights, diameter of the seminiferous tubules as well as better state of spermatogenic cell lineage, Sertoli cells Leydig cells and blood vessels, as compared to group BI. The results indicate atrophy of the testis and revival after cessation of estrogen treatment