Synthesis of some peptides containing o-and p-amino methyl benzoate, aminobenzamide, phthalamide and therephthalamide residues

ABSTRACT

It is well established that several substituted o-and p-aminobenzoic acid and phthalamide derivatives have played an important role as nitrogen donor ligands in the synthesis of a wide variety of metal complexes. They also possess bacteriostatic, tuberculostatic and fungicidal activities. Recently, we have reported the synthesis of several N-tosylpeptide derivatives and some of which were found to be biologically active. As a continuation of this work the synthesis of some N-tosyldi-and tri-glycyl-o-[or-p-] amino methylbenzoate and the corresponding N, N'-bis derivatives of c-and p-aminobenzamide, phthalamide and terephtalamide derivatives [VII-XXII] and the study of their biological activities and copper [II] complexes are described in this note