Effect of lead toxicity on ultrastructure of bowman's capsule of adult rats

ABSTRACT

This study was designed to evaluate the lead induced toxic effects on the ultrastructure of adult rat Bowman's capsule, and comprised 18 rats. The animals were divided into two equal groups, [n=9] control group given pure distilled water and study group given a 0.13% lead acetate solution in drinking water. After 8 weeks exposure, rats were sacrificed and their kidneys were removed and a small piece of renal cortex was fixed and sections were prepared for electron microscopic examination. The parietal cells of Bowman's capsule of the experimenatal group showed signs of damage to nucleus and organelles, with abundance of cytoplasmic vacuoles and phagolysosomes. We can conclude that exposure to lead can induce damage to the parietal cells of Bowman's capsule in rats