TH1/TH2 cytokine patterns in ankylosing spondylitis

ABSTRACT

Thl [IL-2] cytokine and Th2 [IL-10] cytokine were measured in the serum of 15 patients with ankylosing spondylitis [AS] and their relation with the disease activity were assessed. They were 12 males and 3 females. Another 12 healthy persons matched for age and sex were chosen as a control group. All The patients were subjected to clinical assessment and Laboratory investigations. IL-2 and IL-10 were measured using ELISA Technique. The Results showed a significant decrease in IL-2 and a significant increase in IL-10 in Ankylosing spondylitis patients as compared to the controls. Serum IL-2 showed a negative significant correlation with Laboratory parameters [ESR, CRP] and clinical parameters such as vertebral mobility and morning stiffness, while IL-10 showed a positive significant correlation with the Laboratory and clinical parameters of activity from the previous results we could conclude that the impaired IL-2 [Thl] and the increased IL-10 [Th2] cytokine levels and their correlation with the clinical and Laboratory criteria of As. could help in the assessment of the disease and follow up of the outcome of As therapeutic modalities